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Buy Melanotan II Peptide

Melanotan II, also known as MT-2 and Melanotan 2, is a synthetic analogue of the peptide hormone alpha-melanocyte stimulating hormone (α-MSH) that is primarily used for its tanning effects. It works by stimulating melanin production in the skin, leading to increased pigmentation and a darker tan, potentially reducing the skin’s sensitivity to UV exposure, and has also been linked to improving the sexual functioning of men.

Melanotan II Nasal Spray

Which Melanotan 2 Should You Choose?

Depending on the objectives of your study PharmaGrade Store New Zealand offers a wide range of Melanotan 2 peptide products to suit your needs:

Buy Melanotan II Peptide for Research

Melanotan 2 is a synthetic peptide analogue of the naturally occurring hormone alpha-melanocyte stimulating hormone (α-MSH). It is most commonly known for its ability to induce skin tanning by promoting melanin production.

Melanin is the pigment responsible for the colour of the skin, hair, and eyes, and its increased production leads to darkening of the skin, providing a tan-like appearance.

When administered, Melanotan 2 binds to melanocortin receptors in the human skin, specifically activating melanogenesis, the process responsible for melanin synthesis. This stimulation results in the darkening of the skin, akin to a natural tan, without the need for extensive sun exposure. By encouraging melanin production  Melanotan II may also offer potential photoprotective effects, reducing the skin’s susceptibility to UV damage and sunburnsm [1].

Additionally studies have found that Melanotan II products could cause a loss of appetite and be used as a therapeutic agent for sexual dysfunction. 

Benefits of Melanotan 2 Peptide

New Zealand Researchers have identified that Melanotan 2 could have the following benefits:

  • Induces skin tanning by stimulating melanin production – Melanotan 2 induces tanning by activating melanogenesis, the process of melanin production, through stimulation of melanocortin receptors in the skin [2].
  • Potential photoprotective effects, reducing susceptibility to UV damage – case reports it may have potential photoprotective effects stem from its ability to increase melanin levels in the skin, providing a natural defence mechanism against UV radiation and reducing the risk of sunburns and UV-induced skin damage including melanoma and skin cancer [3].
  • Appetite Suppressant – Melanotan 2 has been reported by some users to act as an appetite suppressant indirectly, possibly due to its influence on melanocortin receptors that are involved in regulating appetite and metabolism [4].
  • Libido Enhancing – Melanotan 2’s potential to improve libido is thought to be linked to its activation of melanocortin receptors in the brain, which may influence sexual arousal and desire, although further research is needed to fully understand this mechanism [5].

Scientific Research of Melanotan 2

Research on Melanotan 2 peptide, also known as MT-II, has focused on its super potent melanotropic activity and potential applications. New Zealand Studies have explored novel analogues of MT-II with enhanced effects on melanin production in skin cells.

Additionally, research has delved into the development of sustained delivery systems for Melanotan II, aiming to optimize its therapeutic efficacy. Investigations into the permeability of Melanotan II through cell membranes have been conducted to enhance understanding of its bioavailability [6].

Moreover, there have been reports linking the use of Melanotan II to systemic toxicity and adverse effects, emphasizing the importance of further research on its safety profile and potential risks.

Melanotan II Specifications:

View PharmaGrade Store Melanotan 2 HPLC Certificate here.

Sequence: Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)-NH2

Molecular Formula: C50H69N15O9

Molecular Weight: 1024.2 g/mol

Buy Melanotan 2 Peptide online from PharmaGrade.Store New Zealand today!

Melanotan 1 and Melanotan 2

Melanotan I and Melanotan II Stack

Researchers believe that combining Melanotan 1 and Melanotan 2 peptides can potentially lead to synergistic effects, enhancing the overall tanning response by stimulating melanin production through different pathways. 

Buy Melanotan I and Melanotan II stack here.

What's the Difference Between Melanotan I and Melanotan II?

Melanotan I and Melanotan II peptides are synthetic analogues of the naturally occurring hormone alpha-melanocyte-stimulating hormone (α-MSH), but they differ in their specific amino acid sequences.

Melanotan I (afamelanotide) primarily focuses on skin pigmentation and tanning effects by stimulating melanin production, while Melanotan II has a broader spectrum of effects, including appetite suppression and potential libido enhancement, in addition to tanning properties [7].

Furthermore, Melanotan II is known for its superpotent melanotropic activity compared to Melanotan I, leading to a more pronounced and rapid tanning response.

These distinctions make each peptide unique in their applications and desired outcomes.

Discover Melanotan I here.

Frequently Asked Questions about Melanotan II

Can I use Melanotan II as a Tanning Agent?

Although research has established that Melanotan II can stimulate the pigmentation of the skin to appear darker, it is still classed as a research peptide, an unregulated drug and not yet approved for human consumption despite unlawful advertising on social platforms. Unapproved supplements could have serious side effects.

Does Melanotan 2 have side effects?

Melanotan products, like any peptide or drug, may have potential side effects. Clinical studies have reported side effects of Melanotan II including nausea, vomiting, facial flushing, appetite suppression, yawning, fatigue, and increased libido. 

Is Melanotan II legal?

Melanotan 2 is not approved by the FDA for use as a tanning agent. In some countries, including the United States and UK, Melanotan 2 is classified as an unregulated and unapproved substance, which means its sale and distribution for tanning purposes are not legal. It’s essential to adhere to local department of health regulations and consult with healthcare professionals regarding the legality and safety of using Melanotan 2 or any similar peptides in your region.

Can Melanotan II cause erections?

One of the reported side effects of Melanotan 2 studies amongst participants is an increase in libido, which may lead to spontaneous penile erections in some individuals.

Further Reading:


Peptides that Change the Game for Fat Loss: Exploring Fat Loss Peptides

Burn Calories

Embark on a fascinating journey through the realm of fat loss peptides, focusing on the potent effects of some of the most researched peptides including Melanotan II, GLP-1 and FTTP Adipotide.  This blog delves into the mechanisms by which different peptides stimulate fat loss, boosts metabolism, and potentially suppresses appetite.

Explore the different mechanisms of fat loss research peptides and how Melanotan II is often considered a weight loss peptide.

Melanotan 1 vs Melanotan 2: Understanding the Differences


In this blog, we dissect the distinct characteristics of Melanotan 1 and Melanotan 2 peptides to unravel their unique roles in tanning and beyond.

Delve into the specifics of how these synthetic analogues of α-MSH differ in their mechanisms of action, potency, and potential benefits. 

Discover the scientific differences between Melanotan 1 and Melanotan 2.

Scientific Research:

[1] Gilhooley E, Daly S, McKenna D. Melanotan II User Experience: A Qualitative Study of Online Discussion Forums. Dermatology. 2021;237(6):995-999.

[2] Boo YC. Up- or Downregulation of Melanin Synthesis Using Amino Acids, Peptides, and Their Analogs. Biomedicines. 2020 Sep 1;8(9):322.

[3] Ross St, C Barnetson, Terry K.T. Ooi, Liqing Zhuang, et al. [Nle4-D-Phe7]-α-Melanocyte-Stimulating Hormone Significantly Increased Pigmentation and Decreased UV Damage in Fair-Skinned Caucasian Volunteers, Journal of Investigative Dermatology, Volume 126, Issue 8, August 2006, Pages 1869-1878

[4] Eliason NL, Martin L, Low MJ, Sharpe AL. Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food. Neuropeptides. 2022 Dec;96:102289

[5] Bassett PA, Abbara A, Goldmeier D, Comninos AN, Dhillo WS. Melanocortin 4 receptor agonism enhances sexual brain processing in women with hypoactive sexual desire disorder. J Clin Invest. 2022 Oct 3;132(19):e152341.

[6] Evans-Brown, Michael & Dawson, Rob & Chandler, Martin & Mcveigh, Jim. (2009). Use of melanotan I and II in the general population. BMJ. 338. 10.1136/bmj.b566. 

[7] Royalty JE, Konradsen G, Eskerod O, Wulff BS, Hansen BS. Investigation of safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple doses of a long-acting α-MSH analog in healthy overweight and obese subjects. J Clin Pharmacol. 2014 Apr;54(4):394-404.

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